Extensive human phosphorylation -- not on S,T, or Y!

I'm honestly leaving this exciting new study at biorXiV here so that I can remember to get back to it when I get caught up today!  This....

Simple (& surprising?) strategies to find more PTMs on quadrupole Orbitraps

I'm at a loss here. Time for more espresso? The observations in this new study don't gel with my mental framework, but I think this ...

Advancing top down proteomics past 30kDa!!

Okay...before you roll your eyes and assume this is going to feature the custom modified quadrupole Orbitrap with the 7 ion funnels that re...

Profiling the BNP Cardiac marker at rocket speed with CE-QE!

I puzzled over this new study for quite a bit.  First off -- I had never heard of this BNP peptide or how it works, but the important thing ...

Proteome Discoverer 2.2 Column (row?) Interpreter!

Once upon a time, I made a spreadsheet that explained what all the output columns were in a Proteome Discoverer (1.3? or 1.4?) output with m...

Simplify the top down proteomics problem with NeuCode!

Top down proteomics is still tough  -- some of the problems that were really hard 10 years ago are still really hard now. What if we could s...

Sonic speed digestion for complex proteomics samples!

I just got back from a couple weeks in amazingly beautiful southern Portugal. Great climbing, beautiful beaches, cool people, and the best $...